ULTIMATE SUPPORT PRESSURE DETERMINATION FOR SHIELD TUNNEL FACES IN SATURATED STRATA BASED ON SEEPAGE FLOW CONTROL

Existing methods no face no case logo for calculating the ultimate support pressure of tunnel faces do not consider the control of seepage flow.Therefore, a model for calculating the ultimate support pressure under seepage conditions was established based on a two-dimensional water head distribution model and the upper bound theorem of limit analys

Cytokines from the common gamma chain receptor family, such as IL-15, IL-21 and IL-7, show promise for cancer immunotherapy and have been incorporated individually into the immunocytokine approach.However, their efficacy as monotherapy is limited.Here, we investigated the molecular design of tumor-directed trifunctional antibody-cytokine tonic show